The aim of the present study is to enhance the dissolution of ibuprofen in presence of glucosamine. The points of nonvariant equilibrium of the ibuprofen piracetam and ibuprofen urea systems correspond to a 65. To improve its dissolution, ibuprofen solid dispersions sds were prepared, characterized by scanning electron microscopy sem, differential scanning calorimetry dsc, and fourier transform infrared spectroscopy ftir, and evaluated for solubility, and invitro ibuprofen release. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The solid dispersion systems ibuprofenpiracetam and ibuprofenurea have been studied by differential scanning calorimetry. Enhancement of solubility and dissolution characteristics of ibuprofen by solid dispersion technique article pdf available in dhaka university journal of pharmaceutical sciences 111. Solid dispersion technique can be used to enhance the solubility, dissolution. Quantitative analysis of ibuprofen in pharmaceuticals. Ibuprofen serum concentrations and its analgesic effect have been shown to be correlated. Investigation of solid dispersion technique in improvement of. Solid dispersions of ibuprofen were prepared by using peg 20000 and poloxamer 407 in different weight ratios by fusion and solvent evaporation method. It is simple, scalable, convenient method and prepared using numerous processes 3.
Enhancement of solubility, dissolution and bioavailability of. Wayne, nj and magnesium stearate fmc corporation, usa were used as directly compressible. Ibuprofen was the first member of propionic acid derivatives to be introduced in 1969 as a better alternative to aspirin. Solubility and dissolution enhancement of ibuprofen by solid dispersion technique using peg 6000pvp k 30 combination carrier article pdf available january 2012 with 3,504 reads how we. Another example is described to obtain solid dispersions of ibuprofen in poloxamer 407 in order to increase the solubility and consequently the dissolution rate of this drug newa, 2008.
Pdf preparation and evaluation of solid dispersions of ibuprofen. This spectrum was documented in just a single scan which took only 7 seconds to obtain. Design and development of fast dissolving tablets of ibuprofen. Pdf on apr 25, 2007, teofilo vasconcelos and others published ddw103 development of a rapid dissolving ibuprofen solid dispersion find, read and cite. Public assessment report scientific discussion ibuprofen apotex 400 mg capsules, soft ibuprofen nlh2790001mr date. Ibuprofen, solid dispersions, physical mixtures, hydrogenated castor oil, stearic. Physical mixtures pms of ibuprofen were also prepared with the same carrier and in the same drugcarrier ratio 1. Preparation and evaluation of fast dissolving ibuprofen. It has a role as a nonsteroidal antiinflammatory drug, a nonnarcotic analgesic, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an antipyretic, a xenobiotic, an environmental contaminant, a radical scavenger and a drug allergen. Formulation and evaluation of ibuprofen controlled release matrix tablets using its solid dispersion article pdf available in international journal of applied pharmaceutics 112. Pdf preparation, characterization, and dissolution. Formulation and evaluation the oral tablets ibuprofen r. Abstract ibuprofen is a nonsteroidal antiinflammatory drug with poor water solubility. Physicochemical characterization and dissolution study of ibuprofen compressioncoated tablets using locust bean gum negar bashardoust1,2, j.
Product information for auspar caldolor ibuprofen phebra pty ltd pm20100239331 final 2 january 20. Research article enhancement of dissolution rate of ibuprofen by preparing solid dispersion using different methods m. Proton nmr spectrum of 200 mm ibuprofen in cdcl 3 1 h nmr relaxation. In this study solid dispersions sds of ibuprofen were prepared by melt dispersion technique using macrogol 4000 and macrogol 6000 as carrier. Formulation and evaluation of solid dispersions of. Pdf formulation and evaluation of ibuprofen controlled. Formulation and evaluation of solid dispersions of furosemide. Enteric coating of ibuprofen tablets 200 mg using an aqueous dispersion system 101 logies, inc. Evaluation of enhancement of solubility of paracetamol by solid dispersion technique using different polymers concentration anupama singh, pramod kumar sharma, jay gopal meher, rishabha malviya department of pharmaceutical technology, meerut institute of engineering and technology, meerut 250005, u.
Thermodynamic study of the solubility of ibuprofen in acetone and dichloromethane 229 ibp solubility analysis in terms of solubility parameters although experimental solubility is a complex phenomenon, definitions have been proposed in order to explain this important physicochemical property of drugs. The aim of this study was to prepare and evaluate ibuprofen ibu solid dispersion tablets with improved dissolution and less sticking using porous calcium silicate pcs. Essab auniversity of sunderland, faculty of applied sciences, department of pharmacy, health and wellbeing, sunderland, sr1 3sd, uk. Absorption in vivo studies indicate that ibuprofen is well absorbed orally from the suspension formulation, with peak. Major adverse reactions associated with ibuprofen are related to git and include peptic and mucosal ulcers, dyspepsia, severe gastric pain and bleeding, that results in excessive treatment failure. Public assessment report scientific discussion ibuprofen.
Ibuprofen ib is one of the most important nonsteroidal antiinflammatory drugs used in the treatment of inflammatory chronic diseases. To develop a novel ibuprofen loaded solid dispersion system sds with enhanced dissolution rate, binary and ternary solid dispersion were prepared by coprecipitation method using poloxamer407 only and mixture of poloxamer407 with a second polymer such as hpmc 6cps, hpc, kollicoat ir, kollidon va 64 respectively. This drug presents, in the pure state, poor physical and mechanical characteristics and their use in solid dosage forms needs the addition of excipients which improve these properties. Fei han 1, wei zhang 1, ying wang 2,3, ziyue xi 1, lu chen 1, sanming li 1. Thermodynamic study of the solubility of ibuprofen in acetone. Drugdrug solid dispersion is a unique approach to present a poorly soluble drug in an extremely fine state of subdivision to the gastro intestinal fluids. Formulation, physicochemical evaluation, and dissolution. An overview of clinical pharmacology of ibuprofen rabia bushra1 and nousheen aslam2 introduction i buprofen is 2rs142methyl propyl phenyl propionic acid bp. It is one of a group of painkillers called nonsteroidal anti. Dissolution enhancement of aceclofenac tablet by solid. In vivo in vitro evaluation of solid dispersion containing.
Phase equilibria in dispersed solid systems of ibuprofen with. As can be seen, solid dispersions of ibuprofen in hydrogenated castor oil and stearic acid presented a higher percentage of particles with average size higher than m. Solid dispersions by hotmelt extrusion pharmaceutical. Ibpeg 8000 sds were prepared by fusion method using varying. Nov 21, 2008 to improve its dissolution, ibuprofen solid dispersions sds were prepared, characterized by scanning electron microscopy sem, differential scanning calorimetry dsc, and fourier transform infrared spectroscopy ftir, and evaluated for solubility, and invitro ibuprofen release. Department of pharmaceutical sciences, coimbatore medical college, coimbatore. Development and characterization of solid dispersion for. Effects of spray drying and spray chilling on ibuprofen. Apr 15, 2009 the solid dispersion systems ibuprofen piracetam and ibuprofen urea have been studied by differential scanning calorimetry. Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol peg, talc, and pegtalc as dispersion carriers. Pdf on jan 10, 20, abdul wahab and others published preparation and evaluation of solid dispersions of ibuprofen using glucosamine hcl as a carrier.
Ibuprofen is a painkiller, which is available overthecounter, without a prescription. A solid dispersion is defined as a formulation of poorly soluble compounds as solid dispersions might lead to particle size reduction, improved wetting, reduced agglomeration, changes in the physical state of the drug and possibly dispersion on a molecular level, according to the physical state of the solid dispersion. Physicochemical characterization and dissolution study of. Josephine leno jenita1, and parvin zakerimilani3, 1department of pharmaceutics, dayananda sagar college of pharmacy, kumaraswamy, layout, bangalore 560078, karnataka, india. Sustainedrelease solid dispersions of ibuprofen prepared by. Ibuprofen is a nonsteroidal anti inflammatory drug nsaid with analgesic, antipyretic, and. Department pharmaceutics, bapatla college of pharmacy, guntur d, andhra pradesh, india. Investigation of solid dispersion technique in improvement.
The solid dispersion of ibuprofen in cethyl alcohol showed a higher percentage of particles between 500 and m. Solid dispersion of ibuprofen containing peg 6000 in combination with poloxamer 407 at the ratio of 1. Studies in adults have established the doseproportionality of ibuprofen as a single oral dose from 50 to 600 mg for total drug and up to 1200 mg for free drug. Study of binary and ternary solid dispersion of ibuprofen for. So, solid dispersion may be an effective technique to enhance dissolution rate of ibuprofen. This can be attributed to improved wettability and. The solid dispersions of ibuprofenstearic acid and ibuprofenhydrogenated castor oil showed the best flow characteristics compared with pure ibuprofen.
Peak serum ibuprofen levels are generally attained one to two hours after administration. Therefore, the rapid ibuprofen absorption could be a prerequisite for the quick onset of its action. Prolongedrelease solid dispersions of ibuprofen request pdf. Quantitative analysis of ibuprofen 881 procedure for tablets and cream.
Loss of individual surface properties during melting and resolidification as revealed by sem micrographs. To improve its solubility, dissolution, and bioavailability. The paper is devoted to the investigation of microwave irradiation mw for the preparation of solvent free solid dispersion sd. Vinayaka mission college of pharmacy, salem, tamilnadu 2. The points of nonvariant equilibrium of the ibuprofenpiracetam and ibuprofenurea systems correspond to a 65. Furthermore, this study seeks to investigate kneading as a method for the preparation of. Solid dispersions of ibuprofen ibf were prepared by solvent evaporation method using polyethylene glycol 0 peg, talc, and pegtalc as dispersion carriers. Design and development of fast dissolving tablets of ibuprofen v sai kishore, d gowtham kumar, b sudheer and m sandeep. To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions sd were prepared in a relatively easy, simple, quick, inexpensive, and.
Razia begum department of pharmaceutical technology, shri vishnu college of pharmacy, vishnupur, bhimavaram534202, ap, india. Abstract ibuprofen is a propionic acid derivative that belongs to the class nsaids. With single doses up to 800 mg, a linear relationship exists between amount of drug administered and the integrated. Pdf preparation, characterization, and dissolution studies. To develop a novel ibuprofen loaded solid dispersion system sds with enhanced dissolution rate, binary and ternary solid dispersion were prepared by coprecipitation method using poloxamer407 only and mixture of poloxamer407 with a second polymer such as. Thermodynamic study of the solubility of ibuprofen in. Ibuprofen, polyethylene glycol, poloxomer, solid dispersion, fusion. Both t 1 and t 2 values of the exchanging hydroxyl proton can be seen in the spectrum. Figure 1 shows the 1 h nmr spectrum of 200 mm ibuprofen in cdcl 3. Phase equilibria in dispersed solid systems of ibuprofen.
Margret chandira1, debjit bhowmik1, rahul yadav1, b. Therefore, the rapid ibuprofen absorption could be. Improved dissolution and antiinflammatory activity of. With single doses up to 800 mg, a linear relationship exists between amount of drug administered and the integrated area under the serum drug concentration vs time curve. Enhanced dissolution of ibuprofen using solid dispersion. Improved dissolution and antiinflammatory activity of ibuprofenpolyethylene glycol 8000 solid dispersion systems. A total of 20 tablets of each of the two studied pharmaceutical preparations ibuprofen, panfarma, belgrade, serbia and brufen, galenika a.
Preparation and evaluation of solid dispersions of ibuprofen using. Applying supercritical fluid technology to prepare ibuprofen solid. Nonsteroidal antiinflammatory drugs nsaids are generally used for reducing fever and pain caused by inflammation. Formulation, physicochemical evaluation, and dissolution studies of carbamazepine solid dispersions m. Another example is described to obtain solid dispersions of ibuprofen in poloxamer 407 in order to increase the solubility and consequently the dissolution rate. It dissolves in dilute solutions of alkali hydroxides an. Impact assessment of different polymers on physicochemical. Ibuprofen is a biopharmaceutical classification system class ii drug that exhibits poor dissolution rate in the gastrointestinal tract. Study of binary and ternary solid dispersion of ibuprofen. Ibuprofen is a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 42methylpropylphenyl group. Ibuprofen, urea, solid dispersions, dissolution rate. Effects of spray drying and spray chilling on ibuprofen dissolution amal a.
Solid dispersion granules were prepared using waterbased solid dispersion and waterretained pcs with the wet granulation method and a highspeed agitation granulator. Enhancing dissolution profile of diazepam using hydrophilic. Kneading is the simplest process for the preparation of solid dispersion where drug polymers and appropriate. Enhanced dissolution of ibuprofen using solid dispersion with. Prolongedrelease solid dispersions of ibuprofen japs.
Figures 2, 3 and 4 show the relaxation time measurements. Among them, solid dispersion is promising technologies to improve dissolution which is defined as the dispersion of active ingredient in an inert carrier in solid state. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020, wolters kluwer updated. Gupta,1 patel 1mitul g1 2, patel nimesh s, madhulika kedawat,1 dept. Improvement of dissolution rate of ibuprofen by solid dispersion. Pdf solubility and dissolution enhancement of ibuprofen. Enhancement of solubility and dissolution characteristics of. Detailed characterization of the dynamics of ibuprofen in.
We prepared solid dispersions sds of ibuprofen ibu with kollicoat ir as the carrier using a newly developed pulse combustion dryer systemhypulcon. Pdf ddw103 development of a rapid dissolving ibuprofen solid. Unlike oral ibuprofen products which are fdaapproved, topical products containing ibuprofen are not fdaapproved. The purpose of this study was to develop ibuprofen ibpolyethylene glycol peg 8000 solid dispersions sds and investigate them for in vitro dissolution and in vivo antiinflammatory activity. The known excess samples ibuprofen solid dispersions, physical mixtures and pure ibuprofen, 0. Enhancement of solubility, dissolution and bioavailability. It dissolves in dilute solutions of alkali hydroxides an dcarbonates ph. Food and drug administration fda issued information for healthcare providers and consumers regarding unapproved topical combination products containing ibuprofen. Essab auniversity of sunderland, faculty of applied sciences, department of pharmacy, health and wellbeing, sunderland, sr1 3sd, uk buniversity of tanta, faculty of pharmacy, egypt abstract.
Enteric coating of ibuprofen tablets 200 mg using an. Ibuprofenpolyethylene glycol 8000 peg 8000 solid dispersions sds with different drug loadings were prepared, characterized by scanning electron microscopy sem and differential scanning calorimetry dsc, and evaluated for solubility, invitro release, and oral bioavailability of ibuprofen in rats. Preparation and evaluation of ibuprofen solid dispersion. Furthermore, this study seeks to investigate kneading as. Solid dispersion sd technology has attracted considerable interest as an efficient means of improving the dissolution rate, and hence, the bioavailability of a range of hydrophobic drugs. Effect of water soluble polymers on dissolution enhancement of. This product information was approved at the time this a uspar. It is established that these systems belong to the eutectic type.
Comparative study of sustainedrelease lipid microparticles and. Preparation, characterization and in vivo evaluation of. The internal rotations and interconformational jumps of ibuprofen in the solid state are fully characterized by the simultaneous analysis of a variety of low. Formulation and evaluation the oral tablets ibuprofen. Extreme high moderate low section 1 chemical product and company identification product name ibuprofen statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. The very slow dissolution rate was observed for pure diazepam and the dispersion of the drug in the polymers considerably enhanced the dissolution rate. Among 41 formulations, solid dispersions of ibuprofen in peg 6000 with each of pvp k30, poloxamer 237, and nacmc at ratio of 2. Powder xray scans of ibuprofen and ibuprofendmpg solid dispersion were made to determine if there is a loss or modification of the pure drugs crystal structure after it is formed into a phospholipid solid dispersion, and to determine if any new crystalline phases may have formed. Ibuprofen is a nonsteroidal antiinflammatory drug that has been widely used in the treatment of mild to moderate pain and fever. To induce closure of a clinicallysignificant patent ductus arteriosus pda in premature infants weighing between 5001500 g and who are. Thus, in this work, solid dispersions of ibuprofen in cethyl alcohol sd ca, stearic. Investigation of solid dispersion technique in improvement of physicochemical characteristics of ibuprofen powder mohammad ali dabbagh, behzad taghipour department of pharmaceutics, school of pharmacy, jundishapour university of medical sciences, ahwaz, iran abstract ibuprofen solid dispersions were prepared by the solvent and fusionsolvent. Biyani anuradha college of pharmacy, chikhli, 443201.